Both hypophosphatemia and hyperphosphatemia are associated with increased mortality in septic patients

Objective This study was intended to explore the relationship between level of serum phosphate and prognosis in septic patients. Methods Data were obtained from public database, which divided into 2 subgroups according whether they complicated with chronic kidney disease. Initial values extracted patients on admission hospital. Propensity score-matched analysis performed. The hypophosphatemia, hyperphosphatemia severity disease explored separately. lowess smoothing technique Kaplan-Meier method utilized for a preliminary levels relation in-hospital mortality 28-day survival. initial graded as 1 (<1.5 mg/dL), (1.5-2.7 3 (2.7-4.5 4 (4.5-5.5 5 (5.5-6.5 6 (6.5-7.5 mg/dL) 7 (> 7.5 mg/dL). Multivariate logistic regression cox used analyse mortality. Results There 4059 cases (17.4%) combined disease, including 419 (10.3%) hypophosphatemia 1091 (26.8%) hyperphosphatemia. 19224 (82.6%) not 3769 (19.6%) 2158 (11.2%) After propensity score-matched, mortality, risk shock significantly higher than normophosphatemia In-hospital shock, occurrence renal replacement therapy, acute failure, maximum clinical score all normophosphatemia. consistent results. In without an independent factor death. When lower, death higher. patients, higher, greater. Conclusions Both are associated increased factors